– GEMORNA is world’s first generative AI platform purpose-built for mRNA design and optimization, demonstrating state-of-the-art efficiency throughout various mRNA therapeutic purposes –
– GEMORNA designs optimized mRNA sequences effectively, considerably accelerating drug discovery by eliminating the necessity for iterative sequence optimization –
– Spin-out from MIT with early-stage angel backing and collaborations with main pharma, biotech and educational establishments –
Raina Biosciences Inc., (“Raina”), an mRNA know-how and therapeutics firm, introduced the publication of knowledge from its generative AI platform in Science. The info helps Raina’s pioneering strategy to mRNA design utilizing its GEMORNA platform to generate novel sequences with superior drug properties over current mRNA discovery strategies. Based by a group with deep RNA therapeutics and AI experience, the Firm’s mission is to rework the mRNA-based therapeutics panorama by accelerating drug discovery timelines and opening new therapeutic areas for mRNA with best-in-class AI-designed therapeutics.
The Science article, titled, “Deep generative fashions design mRNA sequences with enhanced translational capability and stability,” marks a major landmark for optimizing novel mRNAs with enhanced expression and sturdiness to facilitate a variety of therapeutic mRNA purposes.
The article, which was printed on-line at the moment by the journal Science, is summarized as follows:
- Raina’s GEMORNA platform designs superior linear and round mRNA drug molecules with optimized expression ranges and sturdiness, addressing two main points which have restricted the effectiveness of mRNA-based therapeutics
- GEMORNA is very differentiated from prior RNA language fashions developed for predictive duties by way of its direct design of novel sequences from a close to infinite design house
- GEMORNA-generated mRNAs:
- Elicited considerably larger immune response in mice in comparison with a number one commercially obtainable mRNA vaccine sequence, probably supporting mRNA therapeutic vaccine purposes for illnesses equivalent to most cancers
- Achieved as much as a 150-fold enhance in human erythropoietin (hEPO) expression in comparison with an optimized benchmark, probably supporting mRNA medicines for gene remedy
- Demonstrated a 5-fold enhance in CD19 CAR expression and a 2-fold enchancment in sturdiness in comparison with a patented benchmark, leading to almost 100% anti-tumor efficacy in major human T cells, probably supporting mRNA therapies for in vivo CAR-T
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“Raina’s GEMORNA platform is constructed upon a decade of the group’s foundational work in artificial biology and synthetic intelligence,” stated Jicong Cao, Ph.D., Chief Govt Officer and co-founder of Raina Biosciences, and corresponding creator of the Science paper. “We’re excited to work with industry-leading pharma and biotech firms to increase the utilization of mRNA-based therapeutics whereas we put together to construct an inside pipeline.”
“Raina has the potential to rework mRNA therapeutics by quickly and reliably producing novel sequences with larger efficiency, precision and efficacy,” stated Timothy Lu, M.D., Ph.D., Raina’s Chairman of the Board and former MIT college member. “The GEMORNA platform might be a sea change for biopharma firms pursuing mRNA-based medicines past conventional infectious illness vaccines starting from neoantigen most cancers vaccines, in vivo CARs, to gene enhancing or gene remedy purposes.”
Based mostly in Boston, Raina Biosciences is a spinout firm from the Massachusetts Institute of Know-how (MIT), based by leaders in mRNA and AI with a robust monitor document within the biotech {industry}. Jicong Cao, Ph.D. (co-founder, Chief Govt Officer) is a former mRNA researcher at MIT and co-founder of Bota Biosciences. He Zhang, Ph.D. (co-founder, Chief Know-how Officer and first creator of the Science paper) was beforehand a Senior Workers Scientist at Baidu Analysis. Timothy Lu, M.D., Ph.D., Raina’s co-founder and Chairman of the Board, is a serial biotech entrepreneur having co-founded quite a few biotechnology and biopharmaceutical firms, and served on the MIT college from 2010–2022. Joel Edwards, Chief Company Growth Officer, brings over 25 years of management in company technique and deal-making throughout biotech, together with his tenure as Vice President of Company Technique at Ionis Prescription drugs. Raina can be supported by its key scientific advisor Jeff Coller, Ph.D., Bloomberg Distinguished Professor and Inaugural Director of the RNA Innovation Heart at Johns Hopkins College. Raina closed an angel spherical of $5.7 million upon firm formation.
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